Detailed Explanation
28-amino-acid hormone released by cardiac atrial myocytes when stretched by increased blood volume. ANP acts on natriuretic peptide receptor A (NPR-A) to promote sodium and water excretion (natriuresis/diuresis), dilate blood vessels, and suppress the renin–angiotensin–aldosterone system — all working to reduce blood pressure and blood volume.
ANP is synthesized as a 151-amino-acid preprohormone and processed to the active 28-residue form containing a 17-residue disulfide ring essential for receptor binding. ANP belongs to the natriuretic peptide family alongside BNP and CNP. The synthetic analog carperitide is approved in Japan for acute heart failure.
Key Facts
- 28-amino-acid hormone released by cardiac atrial myocytes when stretched by increased blood volume.
- ANP acts on natriuretic peptide receptor A (NPR-A) to promote sodium and water excretion (natriuresis/diuresis), dilate blood vessels, and suppress the renin–angiotensin–aldosterone system — all working to reduce blood pressure and blood volume.
- ANP is synthesized as a 151-amino-acid preprohormone and processed to the active 28-residue form containing a 17-residue disulfide ring essential for receptor binding.
- ANP belongs to the natriuretic peptide family alongside BNP and CNP.
- The synthetic analog carperitide is approved in Japan for acute heart failure.
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