nounIntermediate
Definition
The end of a peptide chain bearing a free carboxyl group (–COOH); by convention, written on the right side of a peptide sequence.

Detailed Explanation

The C-terminus is where translation ends. The ribosome adds amino acids starting from the N-terminus and finishing at the C-terminus. Many post-translational modifications occur at the C-terminus, including amidation (–CONH₂), which is found in roughly half of all neuropeptides and hormones and often enhances biological activity and stability. GLP-1, oxytocin, and substance P are all C-terminally amidated.

Key Facts

  • The C-terminus is where translation ends
  • The ribosome adds amino acids starting from the N-terminus and finishing at the C-terminus
  • Many post-translational modifications occur at the C-terminus, including amidation (–CONH₂), which is found in roughly half of all neuropeptides and hormones and often enhances biological activity and stability
  • GLP-1, oxytocin, and substance P are all C-terminally amidated
Related Terms N Terminus Peptide Bond Residue Backbone

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