Detailed Explanation
CCK is released by I-cells in the duodenum and jejunum in response to dietary fat and protein. It triggers gallbladder contraction (cholecysto- = gallbladder + kinin = movement), pancreatic enzyme secretion, slowed gastric emptying, and satiety signals to the brain via the vagus nerve. CCK acts through two receptor types: CCK-A (primarily gut, gallbladder, pancreas) and CCK-B (primarily brain, also identical to the gastrin receptor). In the brain, CCK functions as a neuropeptide involved in anxiety, pain modulation, and memory.
Key Facts
- CCK is released by I-cells in the duodenum and jejunum in response to dietary fat and protein
- It triggers gallbladder contraction (cholecysto- = gallbladder + kinin = movement), pancreatic enzyme secretion, slowed gastric emptying, and satiety signals to the brain via the vagus nerve
- CCK acts through two receptor types: CCK-A (primarily gut, gallbladder, pancreas) and CCK-B (primarily brain, also identical to the gastrin receptor)
- In the brain, CCK functions as a neuropeptide involved in anxiety, pain modulation, and memory
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