nounIntermediate
Definition
29–30 amino acid neuropeptide widely distributed in the central and peripheral nervous systems.

Detailed Explanation

29–30 amino acid neuropeptide widely distributed in the central and peripheral nervous systems. Galanin modulates pain transmission (analgesic at spinal level), feeding behavior (orexigenic), mood (involved in depression models), and cognition (inhibits acetylcholine release in the hippocampus). It acts through three G-protein-coupled receptors (GalR1, GalR2, GalR3). Galanin is co-expressed with other neurotransmitters including norepinephrine, serotonin, and acetylcholine, suggesting it fine-tunes multiple signaling pathways.

Key Facts

  • 29–30 amino acid neuropeptide widely distributed in the central and peripheral nervous systems.
  • Galanin modulates pain transmission (analgesic at spinal level), feeding behavior (orexigenic), mood (involved in depression models), and cognition (inhibits acetylcholine release in the hippocampus).
  • It acts through three G-protein-coupled receptors (GalR1, GalR2, GalR3).
  • Galanin is co-expressed with other neurotransmitters including norepinephrine, serotonin, and acetylcholine, suggesting it fine-tunes multiple signaling pathways.
Related Terms Neuropeptide Substance P Neuropeptide Y NPY

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