nounIntermediate
Definition
9-amino-acid peptide (PVNFKFLSH) derived from the α-chain of hemoglobin that acts as an inverse agonist at cannabinoid CB1 receptors.

Detailed Explanation

9-amino-acid peptide (PVNFKFLSH) derived from the α-chain of hemoglobin that acts as an inverse agonist at cannabinoid CB1 receptors. It reduces food intake in animal models and modulates pain, anxiety, and blood pressure. Hemopressin was the first endogenous peptide identified as a cannabinoid receptor ligand, opening a new area of 'hemoglobin-derived peptide' research including the related peptides RVD-hemopressin and VD-hemopressin.

Key Facts

  • 9-amino-acid peptide (PVNFKFLSH) derived from the α-chain of hemoglobin that acts as an inverse agonist at cannabinoid CB1 receptors.
  • It reduces food intake in animal models and modulates pain, anxiety, and blood pressure.
  • Hemopressin was the first endogenous peptide identified as a cannabinoid receptor ligand, opening a new area of 'hemoglobin-derived peptide' research including the related peptides RVD-hemopressin and VD-hemopressin.
Related Terms Neuropeptide Receptor Bioactive Peptide

Part of the PeptideBond.com education network