nounIntermediate
Definition
24-amino-acid peptide encoded in the mitochondrial genome (the 16S ribosomal RNA gene region).

Detailed Explanation

24-amino-acid peptide encoded in the mitochondrial genome (the 16S ribosomal RNA gene region). Discovered in 2001, humanin has neuroprotective, cytoprotective, and anti-apoptotic properties. It protects neurons from amyloid-β toxicity in Alzheimer's models and protects cardiomyocytes from ischemia. Together with MOTS-c and SHLP1-6, humanin belongs to the emerging class of mitochondria-derived peptides (MDPs) — signaling molecules encoded in mitochondrial DNA that regulate metabolism, stress responses, and aging.

Key Facts

  • 24-amino-acid peptide encoded in the mitochondrial genome (the 16S ribosomal RNA gene region).
  • Discovered in 2001, humanin has neuroprotective, cytoprotective, and anti-apoptotic properties.
  • It protects neurons from amyloid-β toxicity in Alzheimer's models and protects cardiomyocytes from ischemia.
  • Together with MOTS-c and SHLP1-6, humanin belongs to the emerging class of mitochondria-derived peptides (MDPs) — signaling molecules encoded in mitochondrial DNA that regulate metabolism, stress responses, and aging.
Related Terms MOTS-c Amyloid Neuropeptide

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