nounIntermediate
Definition
Gut-derived peptide hormone released after eating that amplifies glucose-dependent insulin secretion.

Detailed Explanation

Gut-derived peptide hormone released after eating that amplifies glucose-dependent insulin secretion. The two incretins are GLP-1 (from L-cells) and GIP (glucose-dependent insulinotropic polypeptide, from K-cells). Together they account for 50–70% of postprandial insulin secretion — the 'incretin effect.' Both are rapidly degraded by DPP-IV. Incretin-based drugs (GLP-1 agonists and DPP-IV inhibitors) are among the most prescribed diabetes medications worldwide. Tirzepatide is a dual GLP-1/GIP agonist.

Key Facts

  • Gut-derived peptide hormone released after eating that amplifies glucose-dependent insulin secretion.
  • The two incretins are GLP-1 (from L-cells) and GIP (glucose-dependent insulinotropic polypeptide, from K-cells).
  • Together they account for 50–70% of postprandial insulin secretion — the 'incretin effect.
  • ' Both are rapidly degraded by DPP-IV.
  • Incretin-based drugs (GLP-1 agonists and DPP-IV inhibitors) are among the most prescribed diabetes medications worldwide.
Related Terms GLP-1 Insulin Tirzepatide Semaglutide

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