nounIntermediate
Definition
15 kDa glycosylated peptide that links IgA antibodies into dimers and IgM antibodies into pentamers.
Detailed Explanation
15 kDa glycosylated peptide that links IgA antibodies into dimers and IgM antibodies into pentamers. The J-chain is produced by mucosal plasma cells and incorporated during antibody assembly. It is essential for polymeric immunoglobulin receptor (pIgR) binding and subsequent transport of secretory IgA across mucosal epithelium into the gut lumen, saliva, tears, and breast milk — making it a key component of mucosal immunity.
Key Facts
- 15 kDa glycosylated peptide that links IgA antibodies into dimers and IgM antibodies into pentamers.
- The J-chain is produced by mucosal plasma cells and incorporated during antibody assembly.
- It is essential for polymeric immunoglobulin receptor (pIgR) binding and subsequent transport of secretory IgA across mucosal epithelium into the gut lumen, saliva, tears, and breast milk — making it a key component of mucosal immunity.
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