nounIntermediate
Definition
Peptide hormone family (kisspeptin-54, -14, -13, -10) encoded by the KISS1 gene.

Detailed Explanation

Peptide hormone family (kisspeptin-54, -14, -13, -10) encoded by the KISS1 gene. Kisspeptin is the master upstream regulator of reproductive function: it stimulates GnRH neurons in the hypothalamus, which triggers the LH/FSH cascade that drives puberty, ovulation, and testosterone production. Loss-of-function mutations in kisspeptin or its receptor (KISS1R/GPR54) cause hypogonadotropic hypogonadism and absence of puberty. Kisspeptin is being developed as a diagnostic and therapeutic tool for reproductive disorders and is also studied as a metastasis suppressor (KISS1 was originally discovered as a metastasis-suppressor gene).

Key Facts

  • Peptide hormone family (kisspeptin-54, -14, -13, -10) encoded by the KISS1 gene.
  • Kisspeptin is the master upstream regulator of reproductive function: it stimulates GnRH neurons in the hypothalamus, which triggers the LH/FSH cascade that drives puberty, ovulation, and testosterone production.
  • Loss-of-function mutations in kisspeptin or its receptor (KISS1R/GPR54) cause hypogonadotropic hypogonadism and absence of puberty.
  • Kisspeptin is being developed as a diagnostic and therapeutic tool for reproductive disorders and is also studied as a metastasis suppressor (KISS1 was originally discovered as a metastasis-suppressor gene).
Related Terms LHRH Hormone Neuropeptide

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