nounIntermediate
Definition
Left-handed (levorotatory) stereoisomer of an amino acid.

Detailed Explanation

Left-handed (levorotatory) stereoisomer of an amino acid. By convention, the L-configuration places the amino group on the left in a Fischer projection. Almost all amino acids in biological peptides and proteins are L-form — a homochirality that is one of biology's deepest mysteries. The preference likely arose early in the origin of life and has been maintained by the chirality of the ribosome, which strongly favors L-amino acid substrates. D-amino acids occur naturally in some bacterial products and can accumulate in aged tissues.

Key Facts

  • Left-handed (levorotatory) stereoisomer of an amino acid.
  • By convention, the L-configuration places the amino group on the left in a Fischer projection.
  • Almost all amino acids in biological peptides and proteins are L-form — a homochirality that is one of biology's deepest mysteries.
  • The preference likely arose early in the origin of life and has been maintained by the chirality of the ribosome, which strongly favors L-amino acid substrates.
  • D-amino acids occur naturally in some bacterial products and can accumulate in aged tissues.
Related Terms D-Amino Acid Amino Acid Backbone

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