nounIntermediate
Definition
The sole human cathelicidin antimicrobial peptide: 37 amino acids beginning with two leucines (LL).
Detailed Explanation
The sole human cathelicidin antimicrobial peptide: 37 amino acids beginning with two leucines (LL). Produced by neutrophils, macrophages, and epithelial cells, LL-37 has broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses. Beyond direct killing, LL-37 recruits immune cells (chemotaxis), modulates inflammation, promotes wound healing and angiogenesis, and neutralizes bacterial endotoxin (LPS). It forms an amphipathic α-helix that disrupts microbial membranes. LL-37 deficiency is associated with increased susceptibility to infections, and excess LL-37 may contribute to autoimmune conditions like psoriasis and rosacea.
Key Facts
- The sole human cathelicidin antimicrobial peptide: 37 amino acids beginning with two leucines (LL).
- Produced by neutrophils, macrophages, and epithelial cells, LL-37 has broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses.
- Beyond direct killing, LL-37 recruits immune cells (chemotaxis), modulates inflammation, promotes wound healing and angiogenesis, and neutralizes bacterial endotoxin (LPS).
- It forms an amphipathic α-helix that disrupts microbial membranes.
- LL-37 deficiency is associated with increased susceptibility to infections, and excess LL-37 may contribute to autoimmune conditions like psoriasis and rosacea.
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