Detailed Explanation
13-amino-acid peptide found in both the central nervous system and the gastrointestinal tract. In the brain, neurotensin modulates dopamine signaling in mesolimbic pathways, regulates body temperature (hypothermia), and has analgesic properties independent of opioid receptors.
In the gut, it is released by N-cells in the ileum in response to dietary fat and stimulates intestinal motility, pancreatic secretion, and intestinal growth. Neurotensin receptor 1 (NTR1) is overexpressed in many cancers (pancreatic, colon, breast), making it a target for tumor imaging and targeted drug delivery. Radiolabeled neurotensin analogs are being developed for cancer diagnostics.
Key Facts
- 13-amino-acid peptide found in both the central nervous system and the gastrointestinal tract.
- In the brain, neurotensin modulates dopamine signaling in mesolimbic pathways, regulates body temperature (hypothermia), and has analgesic properties independent of opioid receptors.
- In the gut, it is released by N-cells in the ileum in response to dietary fat and stimulates intestinal motility, pancreatic secretion, and intestinal growth.
- Neurotensin receptor 1 (NTR1) is overexpressed in many cancers (pancreatic, colon, breast), making it a target for tumor imaging and targeted drug delivery.
- Radiolabeled neurotensin analogs are being developed for cancer diagnostics.
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