Detailed Explanation
Gut peptide hormone released by I-cells in the duodenum and jejunum in response to dietary fat and protein. CCK has four major actions: stimulating gallbladder contraction (cholecysto = gallbladder, kinin = movement), triggering pancreatic enzyme secretion, slowing gastric emptying, and signaling satiety to the brain via vagal afferents. It exists in multiple bioactive forms (CCK-8, CCK-33, CCK-58).
CCK acts through CCK-A (primarily gut) and CCK-B (primarily brain, identical to the gastrin receptor) receptors. In the brain, CCK functions as a neuropeptide involved in anxiety, panic, pain modulation, and memory. CCK-B receptor antagonists have been studied for panic disorder.
Key Facts
- Gut peptide hormone released by I-cells in the duodenum and jejunum in response to dietary fat and protein.
- CCK has four major actions: stimulating gallbladder contraction (cholecysto = gallbladder, kinin = movement), triggering pancreatic enzyme secretion, slowing gastric emptying, and signaling satiety to the brain via vagal afferents.
- It exists in multiple bioactive forms (CCK-8, CCK-33, CCK-58).
- CCK acts through CCK-A (primarily gut) and CCK-B (primarily brain, identical to the gastrin receptor) receptors.
- In the brain, CCK functions as a neuropeptide involved in anxiety, panic, pain modulation, and memory.
- CCK-B receptor antagonists have been studied for panic disorder.
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