nounIntermediate
Definition
Anti-inflammatory tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH).

Detailed Explanation

Anti-inflammatory tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). KPV retains α-MSH's anti-inflammatory properties without its melanogenic (skin-darkening) effects. In preclinical studies, KPV reduces inflammatory cytokines (TNF-α, IL-6, IL-1β), inhibits NF-κB activation, and shows protective effects in animal models of colitis and inflammatory bowel disease. It enters cells via PepT1 transport and accumulates in inflamed intestinal tissue. Not FDA-approved; primarily used in research.

Key Facts

  • Anti-inflammatory tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH).
  • KPV retains α-MSH's anti-inflammatory properties without its melanogenic (skin-darkening) effects.
  • In preclinical studies, KPV reduces inflammatory cytokines (TNF-α, IL-6, IL-1β), inhibits NF-κB activation, and shows protective effects in animal models of colitis and inflammatory bowel disease.
  • It enters cells via PepT1 transport and accumulates in inflamed intestinal tissue.
  • Not FDA-approved; primarily used in research.
Related Terms Melanocortin Tripeptide Bioactive Peptide

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