Definition
A peptide with exactly 3 amino acid residues joined by 2 peptide bonds.

Detailed Explanation

A peptide with exactly 3 amino acid residues joined by 2 peptide bonds. Despite their small size, several tripeptides have profound biological importance. Glutathione (γ-Glu-Cys-Gly) is the body's master intracellular antioxidant, present at millimolar concentrations in cells.

GHK-Cu (Gly-His-Lys + copper) promotes wound healing, collagen synthesis, and skin remodeling. TRH (pGlu-His-Pro-NH₂) controls thyroid function. In digestion, many tripeptides are absorbed intact via the PepT1 intestinal transporter, often more efficiently than free amino acids — making tripeptide supplements highly bioavailable.

The cosmetics industry uses synthetic tripeptides extensively in anti-aging products.

Key Facts

  • A peptide with exactly 3 amino acid residues joined by 2 peptide bonds.
  • Despite their small size, several tripeptides have profound biological importance.
  • Glutathione (γ-Glu-Cys-Gly) is the body's master intracellular antioxidant, present at millimolar concentrations in cells.
  • GHK-Cu (Gly-His-Lys + copper) promotes wound healing, collagen synthesis, and skin remodeling.
  • TRH (pGlu-His-Pro-NH₂) controls thyroid function.
  • In digestion, many tripeptides are absorbed intact via the PepT1 intestinal transporter, often more efficiently than free amino acids — making tripeptide supplements highly bioavailable.
Related Terms Dipeptide Tetrapeptide Glutathione Ghk Cu Trh Peptide Bond

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PeptideDefinition.com provides educational content about peptide science. Not medical advice. Consult a licensed healthcare provider for medical decisions.