nounIntermediate
Definition
Peptide hormone secreted by G-cells in the stomach antrum and duodenum.

Detailed Explanation

Peptide hormone secreted by G-cells in the stomach antrum and duodenum. Gastrin stimulates gastric acid secretion from parietal cells, promotes mucosal growth, and enhances gastric motility. It exists in multiple forms: G-17 (little gastrin, 17 aa) predominates after meals, while G-34 (big gastrin) has a longer half-life. Excessive gastrin (hypergastrinemia) occurs in Zollinger-Ellison syndrome (gastrinoma) and with chronic proton pump inhibitor use. The CCK-B receptor is identical to the gastrin receptor.

Key Facts

  • Peptide hormone secreted by G-cells in the stomach antrum and duodenum.
  • Gastrin stimulates gastric acid secretion from parietal cells, promotes mucosal growth, and enhances gastric motility.
  • It exists in multiple forms: G-17 (little gastrin, 17 aa) predominates after meals, while G-34 (big gastrin) has a longer half-life.
  • Excessive gastrin (hypergastrinemia) occurs in Zollinger-Ellison syndrome (gastrinoma) and with chronic proton pump inhibitor use.
  • The CCK-B receptor is identical to the gastrin receptor.
Related Terms Cholecystokinin CCK Hormone Secretin

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