Detailed Explanation
A peptide with exactly 5 amino acid residues. Biologically important pentapeptides include the enkephalins (Met-enkephalin: Tyr-Gly-Gly-Phe-Met, and Leu-enkephalin: Tyr-Gly-Gly-Phe-Leu), which are endogenous opioid peptides that modulate pain. Thymopentin (Arg-Lys-Asp-Val-Tyr, also called TP-5) is a synthetic pentapeptide derived from thymopoietin that stimulates T-cell differentiation.
Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) is a selective growth hormone secretagogue. In cosmetics, palmitoyl pentapeptide-4 (Matrixyl, palmitoyl-KTTKS) is marketed for anti-wrinkle effects based on its claimed ability to stimulate collagen synthesis. Pentapeptides are efficiently synthesized by SPPS with near-quantitative yields.
Key Facts
- A peptide with exactly 5 amino acid residues.
- Biologically important pentapeptides include the enkephalins (Met-enkephalin: Tyr-Gly-Gly-Phe-Met, and Leu-enkephalin: Tyr-Gly-Gly-Phe-Leu), which are endogenous opioid peptides that modulate pain.
- Thymopentin (Arg-Lys-Asp-Val-Tyr, also called TP-5) is a synthetic pentapeptide derived from thymopoietin that stimulates T-cell differentiation.
- Ipamorelin (Aib-His-D-2-Nal-D-Phe-Lys-NH₂) is a selective growth hormone secretagogue.
- In cosmetics, palmitoyl pentapeptide-4 (Matrixyl, palmitoyl-KTTKS) is marketed for anti-wrinkle effects based on its claimed ability to stimulate collagen synthesis.
- Pentapeptides are efficiently synthesized by SPPS with near-quantitative yields.
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